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Atorlip is a selective, competitive inhibitor of hmg-coa reductase, the rate-limiting enzyme that converts 3-hydroxy-3-methylglutaryl-coenzyme a to mevalonate, a precursor of sterols, including cholesterol.
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Atovastatin ducs total-C, LDL-C and apB in patints with homozygous and htozygous H, nonamilial oms hypcholstolmia and mixd dyslipidmia. Atovastatin alsducs VLDL-C and TG and poducs vaiabl incass in HDL-C and apA-1. Atovastatin ducs total-C, LDL-C, VLDL-C, apB, TG and non-HDL-C and incass HDL-C in patints with isolatd hyptiglycidmia. Atovastatin ducs IDL cholstol (IDL-C) in patints with dysbtalipopotinmia.
Thapy with lipid-alting agnts should b only on componnt multipl isk actintvntion in individuals at signiicantly incasd isk athosclotic vascula disas du thypcholstolmia. Dug thapy is commndd as an adjunct tdit whn th spons ta dit stictd in satuatd at and cholstol and oth nonphamacologic masus alon has bn inadquat. In patints with CHD multipl isk actos CHD, atovastatin can b statd simultanously with dit.
ATOLIP- TABLT might alscaus ctain sid cts. Th common ons amongst thm a constipation, hadach, stomach pain, waknss tc. Howv somtims it might alscaus som sv sid cts lik allgic actions, blood in uin, chst pain, sv back pain, symptoms liv poblms lik yllowing skin ys tc. I ths sv sid cts appa, it is ncssay tsk mdical hlp ight away.
Niacin: Th isk skltal muscl cts may b nhancd whn atovastatin is usd in combination with niacin; a duction in ATOLIP CV dosag should b considd in this stting.
Th isk myopathy duing tatmnt with dugs in this class is incasd with concunt administation cyclospoin, ibic acid divativs, ythomycin, claithomycin, th hpatitis C potas inhibittlapvi, combinations HIV potas inhibitos, including saquinavi plus itonavi, lopinavi plus itonavi, tipanavi plus itonavi, daunavi plus itonavi, osampnavi, and osampnavi plus itonavi, niacin, azol antiungals. Physicians considing combind thapy with ATOLIP CV and ibic acid divativs, ythomycin, claithomycin, a combination itonavi plus saquinavi, lopinavi plus itonavi, daunavi plus itonavi, osampnavi, osampnavi plus itonavi, azol antiungals, lipid-modiying doss niacin should caully wigh th potntial bnits and isks and should caully monitpatints any signs symptoms muscl pain, tndnss, waknss, paticulaly duing th initial months thapy and duing any piods upwad dosag titation ith dug. Low stating and maintnanc doss ATOLIP CV should b considd whn takn concomitantly with th aomntiond dugs. Piodic CPK dtminations may b considd in such situations, but th is nassuanc that such monitoing will pvnt th occunc sv myopathy.
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after completing the 12-week study, eligible patients were assigned to atorlip-ez ezetimibe co-administered with fenofibrate or fenofibrate monotherapy for an additional 48 weeks.