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It is rapidly absorbed and diffuses readily into all fluids and tissuesThe plasma half-lifewhich is genetically determinedvaries from less than 1 hour in fast acetylators to more than 3 hours in slow acetylatorsIt is largely excreted in the urine within 24 hoursmostly as inactive metabolites.

Isoniazid is an antibioticIt prevents tuberculous bacteria from multiplying in the body.

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a recent report suggests an increased risk of fatal hepatitis associated with dom-isoniazid among women, particularly black and hispanic women.

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