2017, louisiana state university health sciences center new orleans, giacomo s review renagel 800 mg, 400 mg.
Information about Renagel.
BMay be acceptableEither animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
Patients with renal insufficiency may develop hypocalcaemia or hypercalcaemiaRenagel does not contain calciumSerum calcium levels should be monitored as is done in normal follow-up of a dialysis patientElemental calcium should be given as a supplement in case of hypocalcaemia.
Reduced levels of ciclosporinmycophenolate mofetil and tacrolimus have been reported in transplant patients when coadministered with sevelamer hydrochloride without any clinical consequencesi.e graft rejectionThe possibility of an interaction cannot be excluded and a close monitoring of blood concentrations of mycophenolate mofetilciclosporin and tacrolimus should be considered during the use of combination and after its withdrawal.
In very rare casesintestinal obstruction and ileus/subileus have been observed in patients during treatment with sevelamer hydrochlorideConstipation may be a preceding symptomPatients who are constipated should be monitored carefully while being treated with sevelamer hydrochlorideRenagel treatment should be re-evaluated in patients who develop severe constipation or other severe gastrointestinal symptoms.
This is a summary of the European public assessment reportEPARIt explains how the Committee for Medicinal Products for Human UseCHMPassessed the studies performedto reach its recommendations on how to use the medicine.
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