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Esomeprazole was negative in the Ames mutation testin the in vivo rat bone marrow cell chromosome aberration testand the in vivo mouse micronucleus testEsomeprazolehoweverwas positive in the in vitro human lymphocyte chromosome aberration testOmeprazole was positive in the in vitro human lymphocyte chromosome aberration testthe in vivo mouse bone marrow cell chromosome aberration testand the in vivo mouse micronucleus test.
Triple TherapyNEXIUM plus amoxicillin and clarithromycinNEXIUMin combination with amoxicillin and clarithromycinis indicated for the treatment of patients with Hpylori infection and duodenal ulcer diseaseactive or history of within the past 5 yearsto eradicate HpyloriEradication of Hpylori has been shown to reduce the risk of duodenal ulcer recurrencesee DOSAGE AND ADMINISTRATION and Clinical Studies
A preand postnatal development study in rats with esomeprazole strontiumusing equimolar doses compared to esomeprazole magnesium studyproduced similar results in dams and pups as described above.
Hypomagnesemiasymptomatic and asymptomatichas been reported rarely in patients treated with PPIs for at least three monthsin most cases after a year of therapySerious adverse events include tetanyarrhythmiasand seizuresIn most patientstreatment of hypomagnesemia required magnesium replacement and discontinuation of the PPI.
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i also suffer from other minor digestive ailments and take, among other things, nexium.
