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You may have increased sexual urgesunusual urges to gambleor other intense urges while taking this medicationTalk with your doctor if you believe you have any intense or unusual urges while taking Eldepryl.

Severe CNS toxicityserotonin syndromehas been reported in patients with the combination of tricyclic antidepressants and selegilineIn one patient receiving amitriptyline and selegiline this included hyperpyrexia and deathand another patient receiving protriptyline and selegiline experienced tremoragitationand restlessness followed by unresponsiveness and death two weeks after selegiline was added.

Serious reactions with signs and symptoms that may include diaphoresisflushingataxiahyperthermiahyper/hypotensionseizurespalpitationdizziness and mental changes that include agitationconfusion and hallucinations progressing to delirium and coma have been reported in some patients receiving a combination of selegiline and fluoxetineSimilar experience has been reported in patients receiving selegiline and two other serotonin reuptake inhibitorssertraline and paroxetineThere is a potential risk of interaction with fluvoxamine and venlafaxine.

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eldepryl may make you feel dizzy, drowsy or slow your reactions, therefore your ability to drive or operate machinery may be affected.

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